Genetic analysis of tubule morphogenesis in Drosophila. (360G-Wellcome-082729_Z_07_Z)

£445,918

An early consequence of the specification of renal cells in the hindgut of Drosophila is that tubule primordia branch out from this tissue. Later these short fat structures extend through the body cavity to form long thin tubules with a highly stereotypical 3-dimensional arrangement. Notably both the morphogenetic events and, in some cases, the genes that regulate, them are conserved between flies and vertebrates. We aim to understand how cell intrinsic factors combine with external cues to cont rol two of these morphogenetic movements; the initial branching events and the subsequent, directed elongation of tubules along defined routes through the body cavity. Specifically our goals are 1.to record details of the cells behaviour during each phase, using microscopy of fixed and living material. We shall focus on changes in cell shape, junctional dynamics and the position of cells relative to one another. 2. to show how differences in the gene expression of different tubule subtypes lead to the morphogenesis exhibited by each type. 3. to identify factors that promote tubule elongation and to understand their activities and interactions 4. to show how external cues promote specific responses in the outgrowing tubules and to relate these to the activity of intrinsic factors.

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Grant Details

Amount Awarded 445918
Applicant Surname Skaer
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2007-07-10T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Project Grant
Internal ID 082729/Z/07/Z
Lead Applicant Prof Helen Skaer
Partnership Value 445918
Planned Dates: End Date 2012-03-31T00:00:00+00:00
Planned Dates: Start Date 2007-11-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England