The CD40-CD154 pathway in FoxP3+ regulatory T cell biology. (360G-Wellcome-082876_Z_07_Z)

£144,363

This project aims to investigate the role of CD40-CD154 signals in the development of Foxp3' regulatory T cells. Specific aims include: 1) Elucidating the genetic events which are manipulated by this signal in pre-committed and committed Foxp3'Tregs 2) Ascertaining whether direct signalling through CD154 molecule is essential for Foxp3'Treg development 3) Determining the genetic and molecular events that lead to dependency on the CD154-CD40 pathway for Foxp3'Treg development in an ageing immune system

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Grant Details

Amount Awarded 144363
Applicant Surname Cuss
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2007-03-23T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title PhD Studentship (Basic)
Internal ID 082876/Z/07/Z
Lead Applicant Mr Steven Cuss
Partnership Value 144363
Planned Dates: End Date 2010-09-30T00:00:00+00:00
Planned Dates: Start Date 2007-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Douglas Fearon