The CD40-CD154 pathway in FoxP3+ regulatory T cell biology. (360G-Wellcome-082876_Z_07_Z)
This project aims to investigate the role of CD40-CD154 signals in the development of Foxp3' regulatory T cells. Specific aims include: 1) Elucidating the genetic events which are manipulated by this signal in pre-committed and committed Foxp3'Tregs 2) Ascertaining whether direct signalling through CD154 molecule is essential for Foxp3'Treg development 3) Determining the genetic and molecular events that lead to dependency on the CD154-CD40 pathway for Foxp3'Treg development in an ageing immune system
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Grant Details
Amount Awarded | 144363 |
Applicant Surname | Cuss |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2007-03-23T00:00:00+00:00 |
Financial Year | 2006/07 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 082876/Z/07/Z |
Lead Applicant | Mr Steven Cuss |
Partnership Value | 144363 |
Planned Dates: End Date | 2010-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2007-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Douglas Fearon |