Regulation of cell adhesion dynamics during epithelial cell movements. (360G-Wellcome-083071_Z_07_Z)
Half way through embryonic development, the epidermis of Drosophila exhibits a gap covered by a different epithelium, the amnioserosa. Dorsal closure is the process whereby interactions between the two epithelia establish epidermal continuity. This process is an excellent model system to study the cellular processes involved in epithelial morphogenesis. While much attention has been focused on the cytoskeleton and its regulation during dorsal closure, little is known about the regulation of the cell-cell adhesion systems which must play a key role in the process ensuring the continuity of the epithelia and mediating their interactions. Here we propose to perform a quantitative cell biological analysis of the regulation and coordination of the components of the adherens junctions during dorsal closure. Using state of the art microscopic techniques we shall probe into the spatial and temporal dynamics of the interactions between DE-Cadherin and D- -catenin, Armadillo, as well as betw een a-catenin and Armadillo, and how these impinge on the coordinated movement of the epidermal sheet. In parallel we shall analyze how these molecular events that take place at the cellular length scale contribute to the behaviour of specific tissues and to the overall morphogenetic movement.
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Grant Details
Amount Awarded | 281392 |
Applicant Surname | Martinez-Arias |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2007-07-10T00:00:00+00:00 |
Financial Year | 2006/07 |
Grant Programme: Title | Project Grant |
Internal ID | 083071/Z/07/Z |
Lead Applicant | Prof Alfonso Martinez-Arias |
Partnership Value | 281392 |
Planned Dates: End Date | 2011-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2008-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |