Regulation of cell adhesion dynamics during epithelial cell movements. (360G-Wellcome-083071_Z_07_Z)

£281,392

Half way through embryonic development, the epidermis of Drosophila exhibits a gap covered by a different epithelium, the amnioserosa. Dorsal closure is the process whereby interactions between the two epithelia establish epidermal continuity. This process is an excellent model system to study the cellular processes involved in epithelial morphogenesis. While much attention has been focused on the cytoskeleton and its regulation during dorsal closure, little is known about the regulation of the cell-cell adhesion systems which must play a key role in the process ensuring the continuity of the epithelia and mediating their interactions. Here we propose to perform a quantitative cell biological analysis of the regulation and coordination of the components of the adherens junctions during dorsal closure. Using state of the art microscopic techniques we shall probe into the spatial and temporal dynamics of the interactions between DE-Cadherin and D- -catenin, Armadillo, as well as betw een a-catenin and Armadillo, and how these impinge on the coordinated movement of the epidermal sheet. In parallel we shall analyze how these molecular events that take place at the cellular length scale contribute to the behaviour of specific tissues and to the overall morphogenetic movement.

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Grant Details

Amount Awarded 281392
Applicant Surname Martinez-Arias
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2007-07-10T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Project Grant
Internal ID 083071/Z/07/Z
Lead Applicant Prof Alfonso Martinez-Arias
Partnership Value 281392
Planned Dates: End Date 2011-06-30T00:00:00+00:00
Planned Dates: Start Date 2008-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England