The magnetoencephalographic signature of genetic and pharmacological variation in catechol-O-methyl transferase (COMT) (360G-Wellcome-083133_Z_07_A)

£2,933

1) To identify whether a functional polymorphism in COMT, known to affect dopamine metabolism and cognitive and emotional processing, influences the localisation and/or timing of cortical activity, as measured using magnetoencephalography (MEG) during performance of various dopamine-dependent neuropsychological tasks. 2} To determine the effects of acute pharmacological inhibition of COMT, using tolcapone, in the same experimental paradigm. 3} To explore the molecular correlates of COMT inhibition in rat brain, using acute and chronic administration of tolcapone, followed by gene expression profiling, qRT -PCR and immunochemical studies. The work will test hypotheses, largely arising from fMRI, about how and where COMT impacts on brain function, and will be of direct relevance to the understanding of the role of COMT in various psychiatric disorders, and the application of COMT inhibitors as therapeutic agents.

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Grant Details

Amount Awarded 2933
Applicant Surname Farrell
Approval Committee Neurosciences And Mental Health
Award Date 2009-02-18T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title PhD Studentship (Basic)
Internal ID 083133/Z/07/A
Lead Applicant Miss Sarah Farrell
Partnership Value 2933
Planned Dates: End Date 2011-09-30T00:00:00+00:00
Planned Dates: Start Date 2009-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East