Interactions and structures in antigenic variation. (360G-Wellcome-083224_Z_07_A)
Recent discoveries have changed traditional views of antigenic variation in trypanosomes1. It is important now to define fundamental facts at the host-parasite interface in the chronic phase of infection. My aims are to answer the following questions: 1. How sequence-related are VSGs that are expressed sequentially in the chronic phase of infection, and do they cross-react serologically? 2. If they are cross-reactive, how do trypanosomes expressing them survive? 3. What are the epitope specificities of responding antibodies? 4. What is the structure of exposed epitopes of the variant surface glycoprotein, and to what extent do naturally present mutations alter them? Answers to those questions will help answer a core question about antigenic variation: 5. What are the contributions to antigenic variation of total gene switching, segmental gene conversion, and point mutation?
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Grant Details
| Amount Awarded | 6075 |
| Applicant Surname | Hall |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2009-10-20T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 083224/Z/07/A |
| Lead Applicant | Mr James Hall |
| Partnership Value | 6075 |
| Planned Dates: End Date | 2011-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-11-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof William Cushley |