An investigation of genes in key beta-cell pathways following the type 2 diabetes WTCCC genome wide association study. (360G-Wellcome-083270_Z_07_Z)
We will test the hypothesis that common variation in beta-cell genes predisposes to type 2 diabetes. We will aim to a) identify the most strongly associated SNPs in five new gene regions already identified, and b) investigate in more detail ~730 genes expressed in key beta-cell pathways. We will first genotype a panel of 768 SNPs that increase coverage in selected beta-cell genes in the 2000 cases and 3000 controls already covered by the 500K chip. This will result in information from approxi mately ~31,000 SNPs from across these beta-cell genes. We will then take the 384 SNPs with the best P values (~P 80% power to detect odds ratios of 1.15-1.2 at p < 1x10-7. We will work with collaborators from the two other largest type 2 diabetes genome scans and UK epidemiological based collections to further increase the confidence of our findings. Finally we will assess the role of newly associated and replicated type 2 diabetes risk variants in pre-diabetic traits including insulin secretion, fasting glucose and birth weight and growth.
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Grant Details
Amount Awarded | 868678 |
Applicant Surname | Frayling |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2007-10-31T00:00:00+00:00 |
Financial Year | 2007/08 |
Grant Programme: Title | Project Grant |
Internal ID | 083270/Z/07/Z |
Lead Applicant | Prof Timothy Frayling |
Other Applicant(s) | Dr Michael Weedon, Prof Andrew Hattersley, Prof Eleftheria Zeggini, Prof Mark McCarthy |
Partnership Value | 868678 |
Planned Dates: End Date | 2012-01-31T00:00:00+00:00 |
Planned Dates: Start Date | 2008-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South West |