Environmental and genetic determinants of obesity and diabetes in India. (360G-Wellcome-083541_Z_07_Z)

Indians are at high risk of diabetes which is attributed to increased central adiposity. Recent discoveries of nine replicated common genes increasing risk of type 2 diabetes and of the FTO gene which also increases the risk of obesity in Europeans will be examined in Indians. Collaborators in this proposal have contributed to these recent discoveries of susceptibility genes. We want to know if these genes have similar effects in Indians and whether migration, a major environmental exposure, results in differential phenotypic expression of obesity and diabetes in people with similar alleles. We will use data from the Indian Migration Study to conduct a) studies of the prevalence of likely risk alleles in the different regions of India, representing its ethnic diversity; b) examine associations between these alleles with obesity and diabetes phenotypes in migrant and non-migrant people; c) examine biological and behavioural mechanisms by which genetic susceptibility operates to prod uce obesity and diabetes. In addition to scientific outputs this research will produce a DNA and phenotypic databank with wide representation of India s population which will be of value to scientists for discovery of genetic variation in a wide range of phenotypes relating to cardiovascular and metabolic disease.

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Grant Details

Amount Awarded 344884
Applicant Surname Ebrahim
Approval Committee Populations and Public Health Funding Committee
Award Date 2007-10-18T00:00:00+00:00
Financial Year 2007/08
Grant Programme: Title Project Grant
Internal ID 083541/Z/07/Z
Lead Applicant Prof Shah Ebrahim
Other Applicant(s) Dr Giriraj Chandak, Prof Dorairaj Prabhakaran, Prof George Davey Smith, Prof Ian Day, Prof John Whittaker, Prof Kolli Reddy, Prof Sanjay Kinra
Partnership Value 344884
Planned Dates: End Date 2013-09-30T00:00:00+00:00
Planned Dates: Start Date 2008-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London