Auxiliary factors for microRNA processing. (360G-Wellcome-084057_Z_07_Z)
We have discovered the existence of auxiliary factors for miRNA processing. Here, we will investigate the mechanism by which hnRNP A1 facilitates the Drosha-mediated processing of miR-18a. We will investigate how the abundance of hnRNP A1 correlates with miR-18a expression and influences the regulation of miR-18a mRNA targets. More importantly, these experiments should shed light on what makes a particular miRNA require an auxiliary factor for its processing. We aim to identify other miRNAs that require hnRNP A1 for their processing and to define the generality of RNA-binding proteins as auxiliary factors for miRNA processing.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 197449 |
| Applicant Surname | Caceres |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2007-10-31T00:00:00+00:00 |
| Financial Year | 2007/08 |
| Grant Programme: Title | Project Grant |
| Internal ID | 084057/Z/07/Z |
| Lead Applicant | Prof Javier Caceres |
| Partnership Value | 197449 |
| Planned Dates: End Date | 2011-04-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-05-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South West |