Epigenomics of common disease. (360G-Wellcome-084071_Z_07_Z)

£1,051,000

The major histocompatibility complex (MHC) and leukocyte receptor complex (LRC) are the two most polymorphic immune loci in the human genome. Both are associated with multiple disease pathologies including most if not all autoimmune diseases. As part of the MHC and LRC Haplotype projects, we have generated the only multi-Mb single haplotype sequences in the human genome, comprehensive gene and variation maps, high-resolution (1.6 kb) and population-specific linkage disequilibrium maps and a first generation of MHC and HLA allele tag SNPs. Building on this existing resource, the following projects are proposed: (1) MHC Haplotype Project, (2) HLA tagSNPs; (3) Reconstructio of the ancestral MHC haplotype sequence in Europeans; (4) LREC Haplotype Project, and (5) Identification of MHC/LRC tans-acting variants.

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Grant Details

Amount Awarded 1051000
Applicant Surname Beck
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2007-08-31T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Project Grant
Internal ID 084071/Z/07/Z
Lead Applicant Dr Stephen Beck
Partnership Value 1051000
Planned Dates: End Date 2012-08-31T00:00:00+00:00
Planned Dates: Start Date 2007-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London