Epigenomics of common disease. (360G-Wellcome-084071_Z_07_Z)
The major histocompatibility complex (MHC) and leukocyte receptor complex (LRC) are the two most polymorphic immune loci in the human genome. Both are associated with multiple disease pathologies including most if not all autoimmune diseases. As part of the MHC and LRC Haplotype projects, we have generated the only multi-Mb single haplotype sequences in the human genome, comprehensive gene and variation maps, high-resolution (1.6 kb) and population-specific linkage disequilibrium maps and a first generation of MHC and HLA allele tag SNPs. Building on this existing resource, the following projects are proposed: (1) MHC Haplotype Project, (2) HLA tagSNPs; (3) Reconstructio of the ancestral MHC haplotype sequence in Europeans; (4) LREC Haplotype Project, and (5) Identification of MHC/LRC tans-acting variants.
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Grant Details
Amount Awarded | 1051000 |
Applicant Surname | Beck |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2007-08-31T00:00:00+00:00 |
Financial Year | 2006/07 |
Grant Programme: Title | Project Grant |
Internal ID | 084071/Z/07/Z |
Lead Applicant | Dr Stephen Beck |
Partnership Value | 1051000 |
Planned Dates: End Date | 2012-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2007-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |