Neural Correlates of Auditory Processing Deficits in Auditory Cortex and Thalamus of BXSB/MpJ Mice. (360G-Wellcome-084364_Z_07_Z)

£211,787

Our aim is to determine whether behavioural deficits in auditory temporal processing are correlated with abnormalities in the responses of auditory cortical and thalamic neurones in BXSB/MpJ mice. These mice are considered to be an animal model for human developmental disorders associated with auditory processing deficits. Approximately half the animals within a BXSB/MpJ litter are ectopic; they have cortical malformations (ectopia) and thalamic abnormalities that resemble those observed in hu mans with developmental disorders like dyslexia. Despite having normal hearing sensitivity, male ectopic mice have difficulty with perception of rapidly changing sounds; such deficits are also typical of dyslexia. We will compare auditory behaviour and auditory cortical and thalamic responses in ectopic male mice with those in non-ectopic males, which do not have auditory processing deficits and therefore serve as genetically matched controls. Key goals are to determine whether neuronal thres holds for gap detection and detection of rapid two-tone oddball stimuli correlate with behavioural thresholds, and whether neuronal minimum response latencies and limits for synchronised following differ between ectopic and non-ectopic mice. These experiments will produce important information about auditory temporal processing in the mouse, and provide insights into the neuronal basis for auditory processing deficits in humans.

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Grant Details

Amount Awarded 211787
Applicant Surname Linden
Approval Committee Cognitive and Higher Systems Funding Committee
Award Date 2008-02-11T00:00:00+00:00
Financial Year 2007/08
Grant Programme: Title Project Grant
Internal ID 084364/Z/07/Z
Lead Applicant Prof Jennifer Linden
Partnership Value 211787
Planned Dates: End Date 2012-01-31T00:00:00+00:00
Planned Dates: Start Date 2009-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London