The potential impact of vaccination on RSV and other respiratory virus pneumonia in the developing country setting. (360G-Wellcome-084633_Z_08_Z)

£1,849,593

Predicting the potential impact of introducing a vaccine into a community requires an in-depth understanding of the interactions between the pathogen and host. Key elements of this association are the mechanism by which the virus spreads between individuals and the nature of the immune response to infection. In the case of RSV, an antigenically variable virus, individuals are repeatedly infected throughout life, and it is the nature of this partial immunity that is of central concern in our stud ies. In particular, we wish to elucidate the role of the partially immune in constraining virus spread, but, also in maintenance of transmission, especially to na ve individuals most at risk of disease, and to establish the role of individual strain specific immunity to population dynamics. We argue also that the environment of other respiratory pathogens may influence the single pathogen:host ecology. We plan an inter-related series of studies, in which immunological, epidemiological, and th eoretical investigations will feed into transmission dynamics models of RSV and other respiratory viruses, by which to assess the impact of vaccine intervention. Our goals are to define optimal vaccine strategies for disease prevention, and provide a suitable framework for their practical evaluation.

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Grant Details

Amount Awarded 1849593
Applicant Surname Nokes
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2008-02-07T00:00:00+00:00
Financial Year 2007/08
Grant Programme: Title Programme Grant
Internal ID 084633/Z/08/Z
Lead Applicant Prof James Nokes
Other Applicant(s) Dr Patricia Cane, Prof Graham Medley
Partnership Value 1849593
Planned Dates: End Date 2014-06-30T00:00:00+00:00
Planned Dates: Start Date 2008-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands