Two-component signalling in Candida albicans. (360G-Wellcome-086048_Z_08_Z)

£190,148

Stress responses are intimately linked with the pathogenicity of Candida albicans, the major systemic fungal pathogen of humans. We have found that diverse environmental stress responses are dependent upon the stress-activated protein kinase (SAPK) Hog1 in C. albicans. However, little is known about how environmental signals are sensed and relayed to the Hog1 pathway. We and others demonstrated in model yeasts that two-component signalling pathways act to relay stress signals to SAPK pathways. S ignificantly, our pilot experiments in C. albicans have shown that the two-component response regulator protein Ssk1 is required for the response to a specific subset of environmental signals that also requires the Hog1 SAPK, indicating Ssk1 to be a major regulator of Hog1. We have also identified a novel two-component signalling protein Crr1 in C. albicans, and our analysis illustrates that Crr1 is important for the oxidative stress response in a mechanism independent of Hog1 activation. This t imely proposal which builds on this strong platform of data has two key goals: (i) to define the two-component signal transduction network that relays environmental signals to the Hog1 SAPK, (ii) to characterise the mechanism of action of the novel two-component protein Crr1 in mediating the oxidative stress response.

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Grant Details

Amount Awarded 190148
Applicant Surname Quinn
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2008-11-10T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Project Grant
Internal ID 086048/Z/08/Z
Lead Applicant Prof Janet Quinn
Other Applicant(s) Prof Brian Morgan
Partnership Value 190148
Planned Dates: End Date 2012-11-30T00:00:00+00:00
Planned Dates: Start Date 2009-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North East