Allergen like molecules in Schistosoma haematobium: roles in human immunity and acute disease. (360G-Wellcome-086154_Z_08_A)

£5,150

This project will be the first systematic study of 1111tigenic proteins from Schistosoma haematobium, a major helminth pathogen of man. lgE-mediated immune mechanisms are central to immunity to parasitic worm infections and allergy. Recombinant forms of S. haematobium Tegumental Allergen-Like (ShTAL) proteins will be used to characterise patterns of anti-ShTAL lgE responses and IgE-mediated effector functions in human cohorts living in S. haematobium endemic areas of Mali, and in travellers returned to UK with recently acquired infections. These data will be analysed in relation to human susceptibilitY and immunity to infection, the regulation of human IgE and lgE-mediated effector mechanisms, and acute and chronic schistosomiasis morbidity. Specific aims: To identify tegumental allergen-like (TAL) proteins in S. haematobium using adult worm and egg EST databases. To create expression profiles of S. haematobium TALs (ShTALs). To express and purify recombinant ShTAL proteins. To establish patterns of antibody isotype responses to these ShT ALs in human sera collections from studies in aS. haematobium high transmission area of Mali. To test the ability of individual ShTALs to trigger human lgE-dependent immune effector mechanisms. To analyse anti-ShTAL antibody isotype responses in relation to age, sex, intensity of infection and the effects of chemotherapy. To analyse antibody isotype responses to the ShTALs (and circulating cytokine levels) in relation to human immunity, reinfection and urogenital morbidity. To analyse anti-ShTAL IgE and IgG subclass antibody responses and passive and active histamine release, in travellers returned to UK with S. haematobium infection.

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Grant Details

Amount Awarded 5150
Applicant Surname Dickinson
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2011-08-31T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 086154/Z/08/A
Lead Applicant Ms Harriet Dickinson
Partnership Value 5150
Planned Dates: End Date 2012-12-31T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Paul Lehner