The molecular cell biology of the Leishmania parasite / host macrophage interface. (360G-Wellcome-086337_Z_08_Z)
The molecular cell biology of the Leishmania parasite I host macrophage interface. Our overall objective is to define the cell biological processes contributing to the Leishmania parasite's success in growing within a parasitophorus vacuole in the host macrophage. We will focus specifically on the role of the short, immotile flagellum which we postulate to have a sensory role. Specific Aims 1. To determine the cell biological events in parasite transformation (promastigote to amastigote) and the establishment of multi- or individual parasitophorous vacuoles. 2. To identify amastigote cell surface proteins, particularly of the flagellum, potentially involved in attachment or interaction with the macrophage parasitophorous vacuole.
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Grant Details
Amount Awarded | 148641 |
Applicant Surname | Wheeler |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2008-05-27T00:00:00+00:00 |
Financial Year | 2007/08 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 086337/Z/08/Z |
Lead Applicant | Dr Richard Wheeler |
Partnership Value | 148641 |
Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2008-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Keith Gull |