The aetiology of anaemia in HIV positive adults in Blantyre, Malawi: The contribution of anaemia of chronic disease and lymphoma. (360G-Wellcome-086559_Z_08_Z)

HIV affects one in seven of the population of Malawi; 19% of HIV+ve adults admitted to the Queen Elizabeth Hospital, Blantyre have severe anaemia (Hb < 8g/dl). Such patients have a high mortality during admission (28%), but survival increases with even modest improvements in anaemia. There are very few systematic studies of HIV related anaemia in Africa. A study in Malawi identified a primary cause of severe anaemia in 67% of HIV-infected adults. No cause for anaemia was identified in 33% of case s but as the study did not assess whether treatment lead to a resolution of anaemia, other aetiologies would have been missed. My hypotheses are i) that in adult populations with a high HIV seroprevalence, severe anaemia is often multi-factorial, and ii) that anaemia of chronic disease (ACD) and sub-clinical lymphomas are significant, but hitherto undiagnosed, causes of severe anaemia. State-of-the-art technologies (e.g. immunocytochemistry, RT-PCR, FISH) will be used to investigate all ca uses of severe anaemia, including those unresponsive to first line treatment, to identify multiple aetiologies. For the first time in Africa this study will utilise trephine biopsies to identify lymphoma and will examine the usefulness of serum erythropoietin in differentiating ACD from other causes of anaemia.

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Grant Details

Amount Awarded 476979
Applicant Surname McKew
Approval Committee International Interview Committee
Award Date 2008-11-20T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Research Training Fellowship
Internal ID 086559/Z/08/Z
Lead Applicant Dr Stephen McKew
Partnership Value 476979
Planned Dates: End Date 2012-11-04T00:00:00+00:00
Planned Dates: Start Date 2009-05-05T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof Robert Heyderman, Prof Saye Khoo