Role of Palmitoylation in Neuronal Function in C. elegans (360G-Wellcome-086737_Z_08_Z)
The overall aim of this project is to determine the role of protein palmitoylation in neuronal function in vivo, using Caenorhabditis elegans as a model organism. Specific objectives are: 1. To characterise the behavioural phenotypes resulting from the systematic mutation of all predicted protein palmitoyl acyl transferases and thioesterases. 2. To determine the tissue-specificity and subcellular localisation of these enzymes. 3. To identify neuronal palmitoylated substrate proteins and their palmitoylation sites 4. To investigate the role of site-specific palmitoylation in the function of selected neuronal proteins.
Where is this data from?
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Grant Details
| Amount Awarded | 139388 |
| Applicant Surname | Edmonds |
| Approval Committee | Physiological Sciences Funding Committee |
| Award Date | 2008-08-29T00:00:00+00:00 |
| Financial Year | 2007/08 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 086737/Z/08/Z |
| Lead Applicant | Mr Matthew Edmonds |
| Partnership Value | 139388 |
| Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | North West |
| Sponsor(s) | Prof Alexei Tepikin |