Genome-wide DNase 1-hypersensitive sites ins byprofile in different mouse strains by DNase-sequencing. (360G-Wellcome-086785_Z_08_A)
1. Construct massively parallel sequencing libraries from DNAse treated DNA obtained from erythroblasts from the reference strain, C57BL6/J. A library with the correct size distribution and validated by qPCR, will be used as the basis for comparison with data from other strains and as validation with array-based methods for DNAse hypersensitivity sites detection. 2. Construction of libraries from eight strains (A/J, AKR/J, C3H/HeJ, BALBc/J, CBA/J, DBA2/J and LP/J) previously used in a genome-wide mapping experiment of multiple phenotypes (included full blood count) 3. Mapping of hypersensitivity sites onto the whole genome sequences of these strains (obtained from the Sanger institute) 4. Validation of the functional involvement of sequence variants and comparison with the position of quantitative trait loci contributing to haematopoietic phenotypes
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Grant Details
Amount Awarded | 1736 |
Applicant Surname | Hosseini |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2010-02-15T00:00:00+00:00 |
Financial Year | 2009/10 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 086785/Z/08/A |
Lead Applicant | Dr Mona Hosseini |
Partnership Value | 1736 |
Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Jonathan Flint |