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Genome-wide DNase 1-hypersensitive sites ins byprofile in different mouse strains by DNase-sequencing. (360G-Wellcome-086785_Z_08_A)

1. Construct massively parallel sequencing libraries from DNAse treated DNA obtained from erythroblasts from the reference strain, C57BL6/J. A library with the correct size distribution and validated by qPCR, will be used as the basis for comparison with data from other strains and as validation with array-based methods for DNAse hypersensitivity sites detection. 2. Construction of libraries from eight strains (A/J, AKR/J, C3H/HeJ, BALBc/J, CBA/J, DBA2/J and LP/J) previously used in a genome-wide mapping experiment of multiple phenotypes (included full blood count) 3. Mapping of hypersensitivity sites onto the whole genome sequences of these strains (obtained from the Sanger institute) 4. Validation of the functional involvement of sequence variants and comparison with the position of quantitative trait loci contributing to haematopoietic phenotypes


15 Feb 2010

Grant details
Amount Awarded 1736
Applicant Surname Hosseini
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2010-02-15T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Studentship (Basic)
Internal ID 086785/Z/08/A
Lead Applicant Dr Mona Hosseini
Planned Dates: End Date 2012-09-30T00:00:00+00:00
Planned Dates: Start Date 2009-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Jonathan Flint
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