The role of plasmalogenphospholipids in obesity and insulin resistance. (360G-Wellcome-086798_Z_08_A)

£53,487

General aims: To investigate the pathogenic role of plasmalogen depletion in the development o he Metabolic Syndrome. Soecific aims: 1) To elucidate the effect of plasmalogen depletion on energy balance, lipid and carbohydrate metabolism. 2) To characterise the metabolic effects of tissue specific plasmalogen depletion in key metabolic organs such as adipose tissue. 3) To determine the therapeutic value of replenishing plasmalogens in models of obesity and insulin resistance. ' 4) To identify the metabolic pathways altered in the context of plasmalogen depletion using a systems biology approach.

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Grant Details

Amount Awarded 53487
Applicant Surname Schmitt
Approval Committee Physiological Sciences Funding Committee
Award Date 2010-02-15T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Studentship (Basic)
Internal ID 086798/Z/08/A
Lead Applicant Ms Iris Schmitt
Partnership Value 53487
Planned Dates: End Date 2012-09-23T00:00:00+00:00
Planned Dates: Start Date 2010-04-24T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Sir Stephen O'Rahilly