The role of plasmalogenphospholipids in obesity and insulin resistance. (360G-Wellcome-086798_Z_08_A)
General aims: To investigate the pathogenic role of plasmalogen depletion in the development o he Metabolic Syndrome. Soecific aims: 1) To elucidate the effect of plasmalogen depletion on energy balance, lipid and carbohydrate metabolism. 2) To characterise the metabolic effects of tissue specific plasmalogen depletion in key metabolic organs such as adipose tissue. 3) To determine the therapeutic value of replenishing plasmalogens in models of obesity and insulin resistance. ' 4) To identify the metabolic pathways altered in the context of plasmalogen depletion using a systems biology approach.
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Grant Details
Amount Awarded | 53487 |
Applicant Surname | Schmitt |
Approval Committee | Physiological Sciences Funding Committee |
Award Date | 2010-02-15T00:00:00+00:00 |
Financial Year | 2009/10 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 086798/Z/08/A |
Lead Applicant | Ms Iris Schmitt |
Partnership Value | 53487 |
Planned Dates: End Date | 2012-09-23T00:00:00+00:00 |
Planned Dates: Start Date | 2010-04-24T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Sir Stephen O'Rahilly |