The relationship between lineage and connectivity in the mouse cerebral cortex. (360G-Wellcome-086806_Z_08_A)
The mechanisms by which cortical circuits are assembled remain largely unclear. Recent evidence has suggested that the excitatory neurons of the cortex preferentially form synapses with clonally related cells, hinting at a potential mechanism for circuitry formation. The goal of my project is to answer the following questions: 1. Do clones of cortical neurons form ordered synaptic connections in vitro? 2. Do clones of cortical neurons respect areal or columnar boundaries in vivo? 3. Do clonally-related cortical neurons preferentially form connections with sibling neurons in vivo? 4. Time permitting, test candidate cellular and molecular mechanisms that underlie this phenomenon.
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Grant Details
Amount Awarded | 36245 |
Applicant Surname | Kirwan |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2010-02-15T00:00:00+00:00 |
Financial Year | 2009/10 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 086806/Z/08/A |
Lead Applicant | Mr Peter Kirwan |
Partnership Value | 36245 |
Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Daniel St Johnston |