The relationship between lineage and connectivity in the mouse cerebral cortex. (360G-Wellcome-086806_Z_08_A)

£36,245

The mechanisms by which cortical circuits are assembled remain largely unclear. Recent evidence has suggested that the excitatory neurons of the cortex preferentially form synapses with clonally related cells, hinting at a potential mechanism for circuitry formation. The goal of my project is to answer the following questions: 1. Do clones of cortical neurons form ordered synaptic connections in vitro? 2. Do clones of cortical neurons respect areal or columnar boundaries in vivo? 3. Do clonally-related cortical neurons preferentially form connections with sibling neurons in vivo? 4. Time permitting, test candidate cellular and molecular mechanisms that underlie this phenomenon.

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Grant Details

Amount Awarded 36245
Applicant Surname Kirwan
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2010-02-15T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Studentship (Basic)
Internal ID 086806/Z/08/A
Lead Applicant Mr Peter Kirwan
Partnership Value 36245
Planned Dates: End Date 2012-09-30T00:00:00+00:00
Planned Dates: Start Date 2009-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Daniel St Johnston