The role of metabolism in alternative macrophage activation in vivo. (360G-Wellcome-087418_Z_08_Z)
Due to the link between metabolism and alternative activation in macrophages discussed below we seek to address the following questions: l What is the role of IL4/ IL13 signalling via the IL4R? chain in induction of alternatively activated macrophages (AAM?) by helminths in vivo? l Do helminthinduced AAM? upregulate a metabolic regime biased towards fatty acid oxidation (FAO)? l What transcriptional processes link the metabolic and immunological components of AAM?? l To what extent is PPAR? involved in the induction and maintenance of AAM? in vivo?
Where is this data from?
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Grant Details
| Amount Awarded | 139701 |
| Applicant Surname | Thomas |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2008-08-29T00:00:00+00:00 |
| Financial Year | 2007/08 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 087418/Z/08/Z |
| Lead Applicant | Dr Graham Thomas |
| Partnership Value | 139701 |
| Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Richard Maizels |