Genetic dissections of hippocampal function. (360G-Wellcome-087736_Z_08_Z)

£1,312,954

The aim is to provide a unifying account of the hippocampus, using the latest molecular biological techniques, along with a novel in vivo voltammetric approach for recording tissue oxygen concentrations. I will investigate the role of synaptic plasticity in two, distinct forms of hippocampus-dependent spatial memory, and test the novel hypothesis that SRM and SWM reflect associative and non-associative information processing respectively. I will test whether these memory processes can be dis sociated on the basis of (i) the nature of LTP induction, (ii) the mechanisms underlying LTP expression/maintenance, and (iii) the hippocampal pathways recruited and the subfields in which plasticity occurs. I will also test whether the amygdala and ventral hippocampus are differentially associated with fear and anxiety respectively. I will use in vivo oxygen voltammetry to measure haemodynamic responses as an index of brain activity in key regions of interest, and compare this signal to oth er electrophysiological correlates of neuronal activity during behaviour. These techniques will also be combined in genetically modified mice in which key components of hippocampal information processing are disrupted. Finally, I will use this approach to study the contribution of ventral hippocampus and amygdala to emotional processing in pre-clinical mouse models of anxiety and depression.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 1312954
Applicant Surname Bannerman
Approval Committee Basic Science Interview Committee
Award Date 2009-04-06T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Senior Research Fellowship Basic Renewal
Internal ID 087736/Z/08/Z
Lead Applicant Prof David Bannerman
Partnership Value 1312954
Planned Dates: End Date 2015-08-31T00:00:00+00:00
Planned Dates: Start Date 2009-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Nicholas Rawlins