Development of fragment-based Hepatitis C (HCV) viral replication inhibitors (360G-Wellcome-087738_Z_08_A)

£1,000,000

Development of fragment-based Hepatitis C (HCV) viral replication inhibitorsAn estimated 170 million people worldwide are infected with HCV with treatment requiring an extended period of therapy and influenced by side effects and low response rates.The Trust has provided £2 million programme related investment to Cambridge based Astex Therapeutics to use their proprietary fragment-based screening approach, Pyramid (TM), to identify and develop novel inhibitors which bind to newly identified regulatory site on a HCV viral protein. Such novel agents would be of significant value in a disease where combination therapy is vital to limiting the emergence of viral resistance.

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Grant Details

Amount Awarded 1000000
Applicant Surname Thompson
Approval Committee Seeding Drug Discovery Committee
Award Date 2010-07-21T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Seeding Drug Discovery Award
Internal ID 087738/Z/08/A
Lead Applicant Dr Neil Thompson
Partnership Value 1000000
Planned Dates: End Date 2010-12-31T00:00:00+00:00
Planned Dates: Start Date 2009-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England