The protective role of neutrophils in human tuberculosis. (360G-Wellcome-087754_Z_08_Z)
There is mounting evidence that neutrophils are powerfully mycobactericidal and may contribute significantly to the early containment of tuberculosis infection. It is also believed that HIV compromises neutrophil number and function, which may in part explain the increased susceptibility of HIV positive people to tuberculosis. This study aims to first assess the relative contribution of neutrophils to mycobacterial restriction compared to other cell types in a whole blood model, before furthe r exploration of the mechanisms of killing. Subsequently the impact of HIV on neutrophil defense against mycobacteria will be investigated, including whether any impairment can be overcome with neutrophil enrichment. The impact of antiretroviral therapy on neutrophil number and function will be explored prospectively, aiming to assess to what extent this explains the improvements in mycobacterial suppression previously seen with this therapy. Simultaneously, in large cohorts of HIV positive people the predictive value of peripheral neutrophil count on risk of acquiring new or active tuberculosis will be evaluated. The ultimate therapeutic aim would be to consider enhancing neutrophil count or function in recently exposed tuberculosis contacts without existing evidence of infection in order to prevent them from developing disease.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 326500 |
Applicant Surname | Lowe |
Approval Committee | International Interview Committee |
Award Date | 2009-03-25T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | Research Training Fellowship |
Internal ID | 087754/Z/08/Z |
Lead Applicant | Dr David Lowe |
Partnership Value | 326500 |
Planned Dates: End Date | 2013-03-31T00:00:00+00:00 |
Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Geoffrey Pasvol, Prof Robert Wilkinson |