NK-cell receptors and function in Hepatitis C virus infection. (360G-Wellcome-087806_Z_08_Z)
NK-cells are delicately balanced by an array of activatory and inhibitory receptors controlling their effector functions. Previous work from our group identified that polymorphisms in killer cell immunoglobulin receptor (KIR) genes encoding for receptors expressed on NK-cells - can influence the outcome of HCV infection. Studies peformed by our group and others have found that the CD94-NKG2A inhibitory receptor is expressed more commonly on NK-cells in hosts with chronic HCV infection compar ed to-NK cells from healthy controls. The aims of this research project are to: (1)Understand how changes in the levels of NKG2A expression affect the level of inhibition of NK-cells and determine the relevance of this in individuals with chronic HCV infection. (2)Determine if secretion of IL-10 in HCV infected individuals is associated with specific sub-populations of NK-cells and thus changes in NK cell receptor expression (3)Investigate the abnormalities of NK cell signalling pathways in chronic HCV to determine the molecular mechanisms underlying these changes
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Grant Details
| Amount Awarded | 224291 |
| Applicant Surname | Cheent |
| Approval Committee | Clinical Interview Committee |
| Award Date | 2009-04-01T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | Research Training Fellowship |
| Internal ID | 087806/Z/08/Z |
| Lead Applicant | Dr Kuldeep Cheent |
| Partnership Value | 224291 |
| Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Howard Thomas |