The role of RGC-32 in Epstein-Barr virus mediated cell-cycle deregulation. (360G-Wellcome-088140_Z_09_Z)
These studies will probe the role played by the novel cell-cycle regulator RGC-32 in the EBV-driven transformation process. This research will study the regulation of RGC-32 expression during EBV transformation and in EBV-infected cell-lines, investigate the mechanism of action of RGC-32 and its role in normal cell-cycle regulation and dissect the structure and function of the protein. Key goals: 1) To study the regulation of RGC-32 expression in EBV-infecetd cells. 2) To study the role of RGC-32 in B-cell transformation by EBV. 3) To probe the mechanism and consequence of CDK1 activation by RGC-32 using: a. Human cell biology and biochemistry b. The Xenopus laevis oocyte system c. Knock-out genetics in the chicken DT40 cell system. 4) To probe the structure of RGC-32 using X-ray crystallography.
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Grant Details
| Amount Awarded | 259609 |
| Applicant Surname | West |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2009-04-30T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | Project Grant |
| Internal ID | 088140/Z/09/Z |
| Lead Applicant | Prof Michelle West |
| Partnership Value | 259609 |
| Planned Dates: End Date | 2012-10-20T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-09-21T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |