Genetics of the people of the british isles and their faces. (360G-Wellcome-088262_Z_09_Z)

£2,067,797

We will add 1,000 samples from the Ancient British western fringe, and from the eastern areas that most reflect the Anglo-Saxon influence, to the 3,500 already collected (rural areas, all four grandparents from the same area). A further 1,500 samples will be collected from populations surrounding the British Isles. Genetic variation determining facial features will be identified through association analysis of candidate gene markers with statistically determined facial characteristics obtained from photographs of the newly collected volunteers and of MZ and DZ twins from the TRU study. Lymphoblastoid cell lines will be grown out from a subset of 1,000 individuals to enable study of the genetic control of tissue specific protein and mRNA levels. Surname distributions will be used to enhance information about the locality of volunteers. Extensive genotyping will be done on the new samples. Analysis of the results of this and previous genotype data, using machine learning algorithms a nd second level haplotyping, together with the facial genetic and certain other markers, will be used to construct a panel of highly informative AIMs. These will be typed on all samples and form the basis for an extensive analysis of population substructure using a wide variety of statistical approaches.

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Grant Details

Amount Awarded 2067797
Applicant Surname Bodmer
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2009-04-28T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Programme Grant
Internal ID 088262/Z/09/Z
Lead Applicant Prof Sir Walter Bodmer
Other Applicant(s) Prof Josef Kittler, Prof Paul Longley, Prof Peter Donnelly, Prof Timothy Spector
Partnership Value 2067797
Planned Dates: End Date 2016-07-11T00:00:00+00:00
Planned Dates: Start Date 2009-07-12T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East