The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates. (360G-Wellcome-088429_Z_09_Z)
The aim of this fellowship is to combine two techniques currently being used to monitor brain injury in adults and neonates; near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS). I will start by developing a novel magnet compatible hybrid optical topography spectrometer (HOTS) that is a combination of broadband and frequency domain spectrometers. HOTS will give regional measurements (2-Dimensional images) of brain tissue total haemoglobin, haemoglobin oxygen saturation, re dox state of cytochrome-c-oxidase, water content, temperature and scattering properties. I will then fuse the HOTS with MRS at an instrumentation level (combining the fibre optics head holder with the MR head coil) and on a software level (image co-registration). MRS scanning provides anatomical information with high spatial resolution measurements of lactate, creatine, phosphocreatine and tissue temperature. The merging of HOTS and MRS can therefore provide complementary physiological informati on. I will test the combined technologies using tissue mimicking phantoms, before a range of in-vivo studies are carried out in adult and neonatal humans and piglets (neonatal animal model). I will then fuse the multimodality data from these studies using systems biology approach utilising a computational model of brain tissue physiology, allowing the translation of the signals from physiological data to clinical information.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 528536 |
Applicant Surname | Tachtsidis |
Approval Committee | Basic Science Interview Committee |
Award Date | 2009-06-23T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | Research Career Development Fellowship |
Internal ID | 088429/Z/09/Z |
Lead Applicant | Prof Ilias Tachtsidis |
Partnership Value | 528536 |
Planned Dates: End Date | 2014-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2010-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Clare Elwell |