Generation of lipid standards for biological studies: oxidized phospholipids generated by activated immune cells. (360G-Wellcome-088540_Z_09_Z)

£192,231

This proposal will establish a resource for generating and supplying oxidized phospholipid standards for biological/biochemical studies to the international research community. The study of these lipids is an emerging field, of relevance to basic mechanisms of physiology and to human disease. Detailed structural characterization, quantitation and biological studies require purified synthetic lipids. We have generated two of these compounds already, but the others ( < 26) require a total synthesis approach that is more time consuming/costly. Once this methodology is established, it can be applied to numerous other related structures, as detailed in our application. We request funding for an organic chemist based in the laboratories of Drs O'Donnell & Bagley. He/she would travel to Dr Porter's lab for up to 3 months to learn advanced organic synthetic chemistry required for this project, then would establish routine synthesis in Cardiff. Related approaches for other lipids are already set- up in Nashville and we do not anticipate any problems. The lipids would be available free of charge to research collaborators (currently 8) but intellectual property will be protected so that they may be commercialized at a later date. A preliminary application for this grant was approved in early 2008.

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Grant Details

Amount Awarded 192231
Applicant Surname O'Donnell
Approval Committee Physiological Sciences Funding Committee
Award Date 2009-05-07T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Biomedical Resources Grant
Internal ID 088540/Z/09/Z
Lead Applicant Prof Valerie O'Donnell
Other Applicant(s) Dr Ginger Milne, Dr Mark Bagley, Prof C McGuigan, Prof N Porter
Partnership Value 192231
Planned Dates: End Date 2013-03-31T00:00:00+00:00
Planned Dates: Start Date 2009-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Wales