How does SOX9 regulate the pancreatic niche of beta cell differentiation?. (360G-Wellcome-088566_Z_09_Z)

£1,411,155

Beta cell regeneration is an ambitious option for the treatment and potential cure of type 1 diabetes. Evidence to date indicates that understanding pancreas development is the best approach for beta cell regeneration strategies in adulthood. My research programme will investigate the transcription factor SOX9 as a critical regulator of beta cell differentiation. I propose that this role depends on SOX9 regulation of the extracellular matrix and extracellular signalling that surrounds the pancre atic progenitor cells to create a niche for beta cell differentiation. By characterising and investigating this niche during development, I anticipate gaining insights into the potential of adult pancreatic ductal cells to undergo beta cell regeneration. Experiments will be conducted using mouse models alongside normal human tissue to attempt to translate data as rapidly as possible into the cell-types of most relevance to patients with type 1 diabetes.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 1411155
Applicant Surname Hanley
Approval Committee Clinical Interview Committee
Award Date 2009-06-17T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Senior Research Fellowship Clinical
Internal ID 088566/Z/09/Z
Lead Applicant Prof Neil Hanley
Partnership Value 1411155
Planned Dates: End Date 2017-01-31T00:00:00+00:00
Planned Dates: Start Date 2010-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof Martin Humphries