How does SOX9 regulate the pancreatic niche of beta cell differentiation?. (360G-Wellcome-088566_Z_09_Z)
Beta cell regeneration is an ambitious option for the treatment and potential cure of type 1 diabetes. Evidence to date indicates that understanding pancreas development is the best approach for beta cell regeneration strategies in adulthood. My research programme will investigate the transcription factor SOX9 as a critical regulator of beta cell differentiation. I propose that this role depends on SOX9 regulation of the extracellular matrix and extracellular signalling that surrounds the pancre atic progenitor cells to create a niche for beta cell differentiation. By characterising and investigating this niche during development, I anticipate gaining insights into the potential of adult pancreatic ductal cells to undergo beta cell regeneration. Experiments will be conducted using mouse models alongside normal human tissue to attempt to translate data as rapidly as possible into the cell-types of most relevance to patients with type 1 diabetes.
Where is this data from?
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Grant Details
Amount Awarded | 1411155 |
Applicant Surname | Hanley |
Approval Committee | Clinical Interview Committee |
Award Date | 2009-06-17T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | Senior Research Fellowship Clinical |
Internal ID | 088566/Z/09/Z |
Lead Applicant | Prof Neil Hanley |
Partnership Value | 1411155 |
Planned Dates: End Date | 2017-01-31T00:00:00+00:00 |
Planned Dates: Start Date | 2010-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North West |
Sponsor(s) | Prof Martin Humphries |