Identification of genes predisposing to tuberculosis in a Russian population and genetic analysis of the host-pathogen interaction. (360G-Wellcome-088838_B_09_Z)

£1,558,700

To discover human genes predisposing to TB we propose to undertake a genome-wide association scan (GWAS) in the Russian (5,000 TB patients and 5,0000 controls) and Ghanaian (2,010 TB patients and 2,346 controls) collections established by the TB-EUROGEN consortium. We will genotype these samples in the Wellcome Trust Sanger Institute using Affy 6.0 array comprising 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation (CNV). We wil l test TB association of these variants and will undertake meta-analysis of the Russian and Ghanaian data and an additional Gambian dataset comprising 1,400 TB cases and 1,400 controls previously genotyped by the Wellcome Trust Case Control Consortium and will compare TB-associated variants in the European and African populations. Additional follow-up of the variants associated with TB exclusively in the European (Russian) population will be done in 2,532 TB patients and > 30,000 controls from Ic eland. Once we complete a GWAS and meta-analyses, we will undertake analysis of interaction between human genes predisposing to TB and M. tuberculosis strains in the Russian and Ghanaian collections to dissect population-specific effects in TB.

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Grant Details

Amount Awarded 1558700
Applicant Surname Peltonen
Approval Committee Genome-Wide Association Studies in Common Disease Committee 2008
Award Date 2009-04-01T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Programme Grant
Internal ID 088838/B/09/Z
Lead Applicant Prof Leena Peltonen
Partnership Value 1558700
Planned Dates: End Date 2011-07-31T00:00:00+00:00
Planned Dates: Start Date 2009-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England