Impact of early infectious and microbial exposures on the development of immunity and allergic inflammatory diseases in children living in a tropical region of Ecuador. (360G-Wellcome-088862_C_09_B)

£150,514

xposures to geohelminth and other infectious and microbial substances in early life provide important signals for the development and regulation of human immunity and are likely to affect the later development of allergic and other inflammatory diseases. Geohelminth infections and enteric microbes are likely to affect also immune responses to vaccines, particularly those administered via the oral route. A birth cohort of 2,300 infants will be used to examine the role of early life infectiou s and microbial exposures on: 1. The development of immunity in early life in the Tropics, 2. The development of protective immunity to vaccines in infancy and childhood. 3. The developmen of inflammation (i.e. allergic sensitization) in childhood, 4. The development of allergic inflammatory diseases, specifically, asthma and eczema, in childhood. 5. Explore gene-geohelminth interactions in the development of allergic sensitization and allergic inflammatory diseases

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Grant Details

Amount Awarded 150514
Applicant Surname Cooper
Approval Committee Science Interview Panel
Award Date 2015-04-01T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Senior Research Fellowship Basic Renewal
Internal ID 088862/C/09/B
Lead Applicant Prof Philip Cooper
Partnership Value 150514
Planned Dates: End Date 2015-12-31T00:00:00+00:00
Planned Dates: Start Date 2015-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London