Impact of early infectious and microbial exposures on the development of immunity and allergic inflammatory diseases in children living in a tropical region of Ecuador. (360G-Wellcome-088862_C_09_B)
xposures to geohelminth and other infectious and microbial substances in early life provide important signals for the development and regulation of human immunity and are likely to affect the later development of allergic and other inflammatory diseases. Geohelminth infections and enteric microbes are likely to affect also immune responses to vaccines, particularly those administered via the oral route. A birth cohort of 2,300 infants will be used to examine the role of early life infectiou s and microbial exposures on: 1. The development of immunity in early life in the Tropics, 2. The development of protective immunity to vaccines in infancy and childhood. 3. The developmen of inflammation (i.e. allergic sensitization) in childhood, 4. The development of allergic inflammatory diseases, specifically, asthma and eczema, in childhood. 5. Explore gene-geohelminth interactions in the development of allergic sensitization and allergic inflammatory diseases
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Grant Details
Amount Awarded | 150514 |
Applicant Surname | Cooper |
Approval Committee | Science Interview Panel |
Award Date | 2015-04-01T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Senior Research Fellowship Basic Renewal |
Internal ID | 088862/C/09/B |
Lead Applicant | Prof Philip Cooper |
Partnership Value | 150514 |
Planned Dates: End Date | 2015-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2015-07-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |