Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort. (360G-Wellcome-088869_B_09_Z)
Using repeated measures collected between ages 13 and 53 years in the British 1946 birth cohort we will test associations between hypothesis-driven candidate genes and novel, empirically derived life-course phenotypes of depression and anxiety, cognition and personality. Our new phenotypes are longitudinal latent classes and latent quantitative traits derived from innovative psychometric approaches that we have piloted (Colman et al, 2007). Goal 1 confirms and 2 extends the phenotypes from m ental health to personality (neuroticism) and cognition ( g ). Goal 3 involves conducting single and multi-marker genetic association studies exploring the impact of sets of genes related to brain development, neurotransmission, cognitive ageing, and endocrine function on these summary measures of life-course risk for health and psychiatric symptoms, personality and cognition. Our overarching hypothesis is that these higher-fidelity, longitudinal measures will represent more valid targets for genetic research than conventional cross-sectional, binary diagnoses. Goal 4 considers the impact of three specified effect modifiers (G x E interaction). These include an early environmental adverse event (childhood separation), pubertal stage (in early teenage years) and a protective factor, educational/occupational attainment. This research will serve as a platform for thematically and methodologically linked collaborative work in other British cohorts, and other relevant samples.
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Grant Details
Amount Awarded | 79356 |
Applicant Surname | Richards |
Approval Committee | Cognitive and Higher Systems Funding Committee |
Award Date | 2009-07-02T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | Project Grant |
Internal ID | 088869/B/09/Z |
Lead Applicant | Dr Marcus Richards |
Other Applicant(s) | Dr Darya Gaysina |
Partnership Value | 79356 |
Planned Dates: End Date | 2012-10-31T00:00:00+00:00 |
Planned Dates: Start Date | 2009-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South West |