Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort. (360G-Wellcome-088869_B_09_Z)

£79,356

Using repeated measures collected between ages 13 and 53 years in the British 1946 birth cohort we will test associations between hypothesis-driven candidate genes and novel, empirically derived life-course phenotypes of depression and anxiety, cognition and personality. Our new phenotypes are longitudinal latent classes and latent quantitative traits derived from innovative psychometric approaches that we have piloted (Colman et al, 2007). Goal 1 confirms and 2 extends the phenotypes from m ental health to personality (neuroticism) and cognition ( g ). Goal 3 involves conducting single and multi-marker genetic association studies exploring the impact of sets of genes related to brain development, neurotransmission, cognitive ageing, and endocrine function on these summary measures of life-course risk for health and psychiatric symptoms, personality and cognition. Our overarching hypothesis is that these higher-fidelity, longitudinal measures will represent more valid targets for genetic research than conventional cross-sectional, binary diagnoses. Goal 4 considers the impact of three specified effect modifiers (G x E interaction). These include an early environmental adverse event (childhood separation), pubertal stage (in early teenage years) and a protective factor, educational/occupational attainment. This research will serve as a platform for thematically and methodologically linked collaborative work in other British cohorts, and other relevant samples.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 79356
Applicant Surname Richards
Approval Committee Cognitive and Higher Systems Funding Committee
Award Date 2009-07-02T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Project Grant
Internal ID 088869/B/09/Z
Lead Applicant Dr Marcus Richards
Other Applicant(s) Dr Darya Gaysina
Partnership Value 79356
Planned Dates: End Date 2012-10-31T00:00:00+00:00
Planned Dates: Start Date 2009-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West