Defining the role of primaquine in malaria elimination. (360G-Wellcome-089179_Z_09_Z)
Primaquine is the only widely available P.falciparum gametocytocide and the only radical treatment for vivax and ovale malaria. It could play a pivotal role in malaria elimination, but it is currently underused because of uncertainty over safety, efficacy and dosage. We propose conducting a series of epidemiological, clinical and pharmacological studies in Thailand to determine the optimum treatment regimens and characterise the safety profile of primaquine. These will define P.vivax relapse rat es, chloroquine and primaquine susceptibility in-vivo, the pharmacokinetic properties of primaquine in adults and children, potential drug interactions, safety in glucose-6-phosphate dehydrogenase deficiency (G6PD), simple methods of oxidant haemolysis risk assessment, and will define the pharmacokinetic-pharmacodynamic relationships for efficacy and safety of primaquine as a gametocytocide. The overall goal is to provide a comprehensive evidence base that would support and guide increased depl oyment of primaquine in control and elimination programmes
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Grant Details
| Amount Awarded | 2352217 |
| Applicant Surname | White |
| Approval Committee | Populations and Public Health Funding Committee |
| Award Date | 2009-05-06T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | Programme Grant |
| Internal ID | 089179/Z/09/Z |
| Lead Applicant | Prof Sir Nicholas White |
| Other Applicant(s) | Prof Francois Nosten, Prof Nicholas Day, Prof Sasithon Pukrittayakamee, Prof Sir David Weatherall |
| Partnership Value | 2352217 |
| Planned Dates: End Date | 2014-06-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-07-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |