New Disease Control Strategies for Foot-and-Mouth Disease. (360G-Wellcome-089209_Z_09_Z)

£188,123

The body of research into FMDV is impressive; over 150 complete genome sequences, a map of polyprotein processing, full-length cDNA clones from which virus can be rescued ( infectious copies ), a non-infectious replicon cDNA system, characterisation of the virus receptor, atomic structures of the virus particle, L proteinase and 3D polymerase, characterisation of immune responses with detailed epitope mapping. There still remain, however, substantial and critical gaps in our knowledge as to ho w this virus replicates in two modes; (i) very rapid cell lysis (3-4hrs), or, (ii) establishment of persistent infections. Even a cursory inspection of the FMDV genome reveals a number of features which are unique to aphthoviruses. Surprisingly, perhaps, the function or contribution to RNA replication of these features is not understood and is not currently being investigated. Our proposed program of research focuses upon questions concerning the replication of virus RNA and the molecular interactions between virus RNA/virus proteins with host-cell proteins using the (non-infectious) FMD replicon system. An essential element of this proposal is to harness the knowledge gained for the design of new, recombinant, forms of the genome to produce attenuated phenotypes: candidates for a new form of disease control live, attenuated, vaccines.

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Grant Details

Amount Awarded 188123
Applicant Surname Ryan
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2009-07-13T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Project Grant
Internal ID 089209/Z/09/Z
Lead Applicant Prof Martin Ryan
Other Applicant(s) Prof David Rowlands, Prof Juergen Haas, Prof Nicola Stonehouse
Partnership Value 188123
Planned Dates: End Date 2013-04-20T00:00:00+00:00
Planned Dates: Start Date 2010-04-21T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland