Designing protein-protein interfaces in Cholera Toxin for synthetic virus-like capsid construction (360G-Wellcome-089308_Z_09_Z)
1. Identify mutable residues in the CTB structure across the proposed interaction surface, which maintains pentameric stability and sugar binding capacity. 2. Use computational modelling to make suggestions as to which residues to mutate to increase pentamer-pentamer binding propensity. 3. Develop aptamers to the A--subunit binding face of CTB as part of developing an ITC/AUC based technique to measure cooperative binding events and detect :weak repulsion or attraction. Structural evaluation of aggregates formed.
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Grant Details
| Amount Awarded | 142657 |
| Applicant Surname | Ross |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-04-21T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 089308/Z/09/Z |
| Lead Applicant | Mr James Ross |
| Partnership Value | 142657 |
| Planned Dates: End Date | 2013-10-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Yorkshire and the Humber |
| Sponsor(s) | Prof Alan Berry |