Time-resolved X-ray crystallography. (360G-Wellcome-089312_Z_09_Z)
1) Develop a statistical approach to distinguish coherent (functionally related) and incoherent (noise) structural changes in time-resolved crystallographic data. 2) Develop the use of single crystal spectroscopy to provide time-resolved ' spectroscopic data correlated with the diffraction experiment : 3) Combine QM/MM (quantum mechanics/molecular mechanics) simulations with the experimentally determined time-resolved structures to yield a full, experimentally restrained, structural and dynamic description of macromolecular function.
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Grant Details
| Amount Awarded | 142657 |
| Applicant Surname | Yorke |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-04-21T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 089312/Z/09/Z |
| Lead Applicant | Dr Briony Yorke |
| Partnership Value | 142657 |
| Planned Dates: End Date | 2014-05-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Yorkshire and the Humber |
| Sponsor(s) | Prof Alan Berry |