The role of Prox1 in the cardiac ent and lymphatic vasculature during development and disease. (360G-Wellcome-089592_Z_09_A)
The role of Prox1 in the cardiac lymphatic vasculature during development and disease a) The hypotheses: i) Prox1 is crucial for cardiac lymphangiogenesis; ii) the development of the cardiac lymphatic system is essential for cardiac morphogenesis and function during development; iii) the developmental lymphangiogenesis programme is reinitiated after injury-induced inflammation in the heart. Thus, the aims of the project are as follows: 1. Characterization of the cardiac lymphatics in wild-type mice 2. Characterization of the cardiac lymphatics in conditional Prox1-mutants (Tie2Cre;Prox11oxPnoxP; Nkx2.5Cre;Prox 11oxPnoxP; WT1 Cre;Prox 11oxPnoxP) 3. Characterization of morphological or functional cardiac defects in conditional Prox1-mutants 4. Determination of whether Prox1 acts cell-autonomously, non cell-autonomously, or both and possible secreted downstream factors 5. Determination of defects in lymphatic endothelial cell (LEC) specification and/or migration in a cardiac context. 6. Examination of neo-lymphangiogenesis in Ml-induced wild-type and Prox1-mutant adult hearts 7. Examination of inflammation progression/chronic inflammation in wild-type and Prox1-mutant hearts post Ml
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Grant Details
Amount Awarded | 29916 |
Applicant Surname | Klotz |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2011-02-21T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 089592/Z/09/A |
Lead Applicant | Ms Linda Klotz |
Partnership Value | 29916 |
Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2011-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Claudio Stern |