The role of Prox1 in the cardiac ent and lymphatic vasculature during development and disease. (360G-Wellcome-089592_Z_09_A)

£29,916

The role of Prox1 in the cardiac lymphatic vasculature during development and disease a) The hypotheses: i) Prox1 is crucial for cardiac lymphangiogenesis; ii) the development of the cardiac lymphatic system is essential for cardiac morphogenesis and function during development; iii) the developmental lymphangiogenesis programme is reinitiated after injury-induced inflammation in the heart. Thus, the aims of the project are as follows: 1. Characterization of the cardiac lymphatics in wild-type mice 2. Characterization of the cardiac lymphatics in conditional Prox1-mutants (Tie2Cre;Prox11oxPnoxP; Nkx2.5Cre;Prox 11oxPnoxP; WT1 Cre;Prox 11oxPnoxP) 3. Characterization of morphological or functional cardiac defects in conditional Prox1-mutants 4. Determination of whether Prox1 acts cell-autonomously, non cell-autonomously, or both and possible secreted downstream factors 5. Determination of defects in lymphatic endothelial cell (LEC) specification and/or migration in a cardiac context. 6. Examination of neo-lymphangiogenesis in Ml-induced wild-type and Prox1-mutant adult hearts 7. Examination of inflammation progression/chronic inflammation in wild-type and Prox1-mutant hearts post Ml

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Grant Details

Amount Awarded 29916
Applicant Surname Klotz
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2011-02-21T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 089592/Z/09/A
Lead Applicant Ms Linda Klotz
Partnership Value 29916
Planned Dates: End Date 2013-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Claudio Stern