The role of phosphorylation in Huntington's disease. (360G-Wellcome-089640_Z_09_Z)
We aim to investigate the role of phosphorylation on the subcellular localisation of the Huntingtin protein, and how this may be aberrant when huntingtin includes the expanded polyglutamine repeat present in Huntington's disease. Specifically I aim to: 1. Characterise the intracellular movement of huntingtin and phosphorylated huntingtin in tissue culture using immortalised striatal cell lines carrying mutant htt and primary cells from mouse models of HD 2. Follow up these findings in human ES and iPS lines carrying the expanded polyQ tract. 3. Characterise the phosphorylated huntingtin nuclear speckles formed in response to growth factors . 4. Examine differential expression and splicing of de novo transcripts in a model system characterised above.
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Grant Details
| Amount Awarded | 141950 |
| Applicant Surname | Bowles |
| Approval Committee | Neurosciences And Mental Health |
| Award Date | 2009-07-21T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 089640/Z/09/Z |
| Lead Applicant | Miss Kathryn Bowles |
| Partnership Value | 141950 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Wales |
| Sponsor(s) | Prof Vincenzo Crunelli |