Wellcome Trust Clinical PhD Programme at the University of Liverpool. (360G-Wellcome-089672_Z_09_Z)

£69,916

The incidence of stroke has increased in low income countries; Malawi is an example of this. A 40% increase in four years in the hospital population has been described. One third of these individuals with stroke are young without established vascular risk factors but are HIV seropositive. HIV infection may be contributing to this increased incidence of stroke. I will examine the relationship of HIV infection and stroke in Malawi and test the primary hypothesis that individuals with HIV infection have an increased risk of stroke compared with community controls. The results could facilitate the rational use of therapies for HIV and vascular disease in primary and secondary prevention, and direct research in novel targeted therapy. The Key goals are: 1. To determine the risk factors for stroke in Malawi, integral to this will be to describe the impact of HIV alone and in combination with other vascular risk factors on the nature and aetiology of stroke 2. To determine the role vascular risk factors and/or HIV infection has in predicating a poor prognosis 3. To gain an insight into the pathogenesis by describing the relationship between endothelial function and stroke in HIV infected individuals

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Grant Details

Amount Awarded 69916
Applicant Surname Benjamin
Approval Committee Neurosciences And Mental Health
Award Date 2009-06-08T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 089672/Z/09/Z
Lead Applicant Dr Laura Benjamin
Partnership Value 69916
Planned Dates: End Date 2010-07-31T00:00:00+00:00
Planned Dates: Start Date 2009-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof David Lalloo