Investigating the effect of prenatal chronic hypoxia on the developmental programming of cardiovascular and metabolic diseases in the adult offspring. (360G-Wellcome-089941_Z_09_A)
The aims of this PhD are to test the following inter-related questions; 1.) Does prenatal hypoxia programme insulin resistance and endothelial dysfunction in later life of the offspring, thus giving rise to metabolic and cardiovascular disease in the same individual? 2.) Does the mechanism underlying these relationships and cardiometabolic outcomes involve oxidative stress? 3.) If so, are the changes preventable by maternal treatment with allopurinol, an antioxidant, thus giving rise to a possible method of clinical intervention?
£64,692 21 Feb 2011