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Investigating the effect of prenatal chronic hypoxia on the developmental programming of cardiovascular and metabolic diseases in the adult offspring. (360G-Wellcome-089941_Z_09_A)

The aims of this PhD are to test the following inter-related questions; 1.) Does prenatal hypoxia programme insulin resistance and endothelial dysfunction in later life of the offspring, thus giving rise to metabolic and cardiovascular disease in the same individual? 2.) Does the mechanism underlying these relationships and cardiometabolic outcomes involve oxidative stress? 3.) If so, are the changes preventable by maternal treatment with allopurinol, an antioxidant, thus giving rise to a possible method of clinical intervention?

£64,692

21 Feb 2011

Grant details
Amount Awarded 64692
Applicant Surname Lusby
Approval Committee Physiological Sciences Funding Committee
Award Date 2011-02-21T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 089941/Z/09/A
Lead Applicant Ms Ciara Lusby
Planned Dates: End Date 2013-10-31T00:00:00+00:00
Planned Dates: Start Date 2010-11-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Sir Stephen O'Rahilly
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