Characterizing the role of AEBP2 at Polycomb-regulated genes (360G-Wellcome-090019_Z_09_Z)
The Polycomb Repressive Complexes (PRCs) are multisubunit chromatin modifying complexes Originally characterized in Drosophila melanogaster as regulators at the homeotic (Hox) genes, these complexes are now known to act as repressors in embryonic stem cells (ES cells) at many genes involved in differentiation. Recently, AE1-binding protein (AEBP2) was discovered to be a stable component of PRG2 complexes (Gao et al, 2002; Gao Zhang, 2004). Furthermore, it has been found to interact genetically with PeG proteins (Guli et al, 2006). AEBP2 contains a zinc finger domain comprised of three zinc fingers. Zinc fingers can interact with DNA sequences, and therefore AEBP2 might target PRG2 complexes to DNA. To determine AEBP2's (AE1-binding protein) preferred DNA binding sequence To investigate whether AEBP2 can bind to RNA To understand the regulation and function of AEBP2 isoforms To investigate the role of AEBP2 in mouse ES (embryonic stem) cells To investigate the role of AEBP2 in development by creating a conditional knock out mouse
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Grant Details
| Amount Awarded | 152906 |
| Applicant Surname | Grijzenhout |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-07-21T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 090019/Z/09/Z |
| Lead Applicant | Miss Anne Grijzenhout |
| Partnership Value | 152906 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Kim Nasmyth |