Poxvirus immune evasion strategies. (360G-Wellcome-090315_Z_09_Z)

£3,485,047

This research programme will study the immune evasion strategies of vaccinia virus (VACV), the vaccine used to eradicate smallpox. The key goals are to i) identify new VACV proteins that interfere with the host response to infection, understand the mechanism of action of these proteins and what host molecules they interact with, and to evaluate the contribution these proteins make to virus virulence and immunogenicity; ii) further characterise VACV proteins that are known to interfere with the h ost response to infection and determine their structures alone and in combination with binding partners, and iii) identify and study the host molecules that sense dsDNA in the cytoplasm and to characterise VACV inhibitors of this(ese). Overall, this programme of work is designed to increase our knowledge of virus pathogenesis and the strategies viruses use to interfere with the host response to infection, to better understand the host innate response to infection, and to build more immunogenic p oxvirus based vaccines.

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Grant Details

Amount Awarded 3485047
Applicant Surname Smith
Approval Committee Principal Research Fellowship Interview Committee
Award Date 2009-12-01T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Principal Research Fellowship Renewal
Internal ID 090315/Z/09/Z
Lead Applicant Prof Geoffrey Smith
Partnership Value 3485047
Planned Dates: End Date 2011-09-30T00:00:00+00:00
Planned Dates: Start Date 2010-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Gavin Screaton