Identification of novel biomarkers by in vitro proton magnetic resonance spectroscopy in acute and acute-on-chronic liver failure. (360G-Wellcome-090542_Z_09_Z)

£140,800

Modern metabonomic methods using magnetic resonance spectroscopy (MRS) combine high resolution spectrometers with highly sophisticated statistical techniques. They have been applied in a variety of situations, but seldom in the field of organ dysfunction in liver failure. In vitro MRS is particularly suited to determining concentrations of molecules involved in these processes (such as ammonia and amino acid trafficking in hepatic encephalopathy). This project will apply these principles to the diagnosis and prediction of outcome in cerebral and renal dysfunction in acute and acute-on-chronic liver failure. Patients will be recruited from the cohort at King's College Hospital (including control groups with confusion and critical illness, but no liver disease) and blood, urine and muscle samples taken. We will make an accurate assessment of ammonia, amino acid, phenolic compound and fatty acid metabolism using MRS and principle components analysis. The aim is to identify biomarkers to better detect these conditions, which may then be used for predicting clinical outcome (including need for transplantation) or translated into simple diagnostic tests.

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Grant Details

Amount Awarded 140800
Applicant Surname Mcphail
Approval Committee Clinical Interview Committee
Award Date 2009-12-03T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Postdoctoral Training Fellowship for Clinicians
Internal ID 090542/Z/09/Z
Lead Applicant Dr Mark Mcphail
Partnership Value 140800
Planned Dates: End Date 2012-11-30T00:00:00+00:00
Planned Dates: Start Date 2010-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Gavin Screaton