Manipulating Iron metabolism through synthesis of Hepcidin analogues. (360G-Wellcome-090555_Z_09_Z)
There is a strong connection between iron metabolism and healthy living, particularly in the elderly and obese where it is found that iron levels can decrease- affected by the level of hepcidin -a small peptide that controls iron homeostasis.[1, 2] Hepcidin binds to, and induces degradation of Ferroportin (an iron efflux protein) involved in intestinal iron absorption, maternal fetal iron transport, iron efflux from the liver, and iron recycling. Dysfunction of the hepcidin pathway may also play an important role in anaemia associated with old age. Understanding the interactions between ferroportin and hepcidin is important to develop drugs that can maintain healthy levels of iron. In this project we will synthesize hepcidin analogues and determine which structural features are important in regulating iron levels and whether these features can be developed into drugs for the treatment of iron deficiency and overload. This project will encompass four major research themes. 1. Synthesis of Hepcidin and analogues 2. In vitro activity. 3. Characterising the nature of the hepcidin-ferroportin interaction. 4. In vivo analysis of agonist/antagonist Hepcidin analogues.
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Grant Details
Amount Awarded | 152244 |
Applicant Surname | Adams |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2009-08-31T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 090555/Z/09/Z |
Lead Applicant | Mrs Anna Adams |
Partnership Value | 152244 |
Planned Dates: End Date | 2013-09-27T00:00:00+00:00 |
Planned Dates: Start Date | 2009-09-28T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Gabriel Waksman |