Manipulating Iron metabolism through synthesis of Hepcidin analogues. (360G-Wellcome-090555_Z_09_Z)

£152,244

There is a strong connection between iron metabolism and healthy living, particularly in the elderly and obese where it is found that iron levels can decrease- affected by the level of hepcidin -a small peptide that controls iron homeostasis.[1, 2] Hepcidin binds to, and induces degradation of Ferroportin (an iron efflux protein) involved in intestinal iron absorption, maternal fetal iron transport, iron efflux from the liver, and iron recycling. Dysfunction of the hepcidin pathway may also play an important role in anaemia associated with old age. Understanding the interactions between ferroportin and hepcidin is important to develop drugs that can maintain healthy levels of iron. In this project we will synthesize hepcidin analogues and determine which structural features are important in regulating iron levels and whether these features can be developed into drugs for the treatment of iron deficiency and overload. This project will encompass four major research themes. 1. Synthesis of Hepcidin and analogues 2. In vitro activity. 3. Characterising the nature of the hepcidin-ferroportin interaction. 4. In vivo analysis of agonist/antagonist Hepcidin analogues.

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Grant Details

Amount Awarded 152244
Applicant Surname Adams
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2009-08-31T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title PhD Studentship (Basic)
Internal ID 090555/Z/09/Z
Lead Applicant Mrs Anna Adams
Partnership Value 152244
Planned Dates: End Date 2013-09-27T00:00:00+00:00
Planned Dates: Start Date 2009-09-28T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Gabriel Waksman