Wellcome Trust PhD Programme for Clinicians at the University of Cambridge: 'Natural and modified variations in human induced pluripotent stem cells'. (360G-Wellcome-090660_Z_09_A)
Human induced pluripotent stem cells (hiPSCs) have revolutionized stem cell biology and have renewed aspirations of moving the field towards clinical therapies. By genetic manipulation, fibroblasts have been shown to re-program to a pluripotent state similar to human embryonic stem cells (hESCs). This would allow for patient specific hiPSCs, generating models for disease as well as immune compatible cell therapies. A major problem in the field is heterogeneity in the derived hiPSCs both in derivation as well as differentiation. Additionally it is unknown whether hiPSCs may be made using cells other than fibroblasts and if these hiPSCs retain an ?epigenetic? memory following differentiation. The knowledge gained from the basis of hiPSC variability will be used to optimise strategies towards clinically relevant therapies. Key goals: 1) Generate hiPSCs from different human tissues 2) Compare hiPSC lines derived from the same individual and so same genetic background 3) Identify new lineage-specific markers through gene expression arrays 4) Explore the differentiation capacity and bias of the different hiPSC lines 5) Investigate epigenetic ?memory? in derivation of hiPSCs and subsequent differentiation 6) Use knowledge of the basis of variability to optimise differentiation strategies 7) Gain robust scientific training in stem cell biology and genetics
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Grant Details
Amount Awarded | 30392 |
Applicant Surname | Rouhani |
Approval Committee | Neurosciences And Mental Health |
Award Date | 2010-06-14T00:00:00+00:00 |
Financial Year | 2009/10 |
Grant Programme: Title | PhD Training Fellowship for Clinicians |
Internal ID | 090660/Z/09/A |
Lead Applicant | Mr Foad Rouhani |
Partnership Value | 30392 |
Planned Dates: End Date | 2012-10-31T00:00:00+00:00 |
Planned Dates: Start Date | 2010-07-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof David Lomas |