Wellcome Trust PhD Programme for Clinicians at the University of Cambridge: 'Natural and modified variations in human induced pluripotent stem cells'. (360G-Wellcome-090660_Z_09_A)

£30,392

Human induced pluripotent stem cells (hiPSCs) have revolutionized stem cell biology and have renewed aspirations of moving the field towards clinical therapies. By genetic manipulation, fibroblasts have been shown to re-program to a pluripotent state similar to human embryonic stem cells (hESCs). This would allow for patient specific hiPSCs, generating models for disease as well as immune compatible cell therapies. A major problem in the field is heterogeneity in the derived hiPSCs both in derivation as well as differentiation. Additionally it is unknown whether hiPSCs may be made using cells other than fibroblasts and if these hiPSCs retain an ?epigenetic? memory following differentiation. The knowledge gained from the basis of hiPSC variability will be used to optimise strategies towards clinically relevant therapies. Key goals: 1) Generate hiPSCs from different human tissues 2) Compare hiPSC lines derived from the same individual and so same genetic background 3) Identify new lineage-specific markers through gene expression arrays 4) Explore the differentiation capacity and bias of the different hiPSC lines 5) Investigate epigenetic ?memory? in derivation of hiPSCs and subsequent differentiation 6) Use knowledge of the basis of variability to optimise differentiation strategies 7) Gain robust scientific training in stem cell biology and genetics

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Grant Details

Amount Awarded 30392
Applicant Surname Rouhani
Approval Committee Neurosciences And Mental Health
Award Date 2010-06-14T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 090660/Z/09/A
Lead Applicant Mr Foad Rouhani
Partnership Value 30392
Planned Dates: End Date 2012-10-31T00:00:00+00:00
Planned Dates: Start Date 2010-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof David Lomas