New infrastructure for EM studies at the University of Leeds. (360G-Wellcome-090932_Z_09_Z)

£364,689

Electron microscopy is a major tool in structural biology. The EM unit within the Astbury Centre for Structural Molecular Biology at the University of Leeds operates a modern FEI T-F20 microscope for high-resolution work. For preliminary cryo-EM studies we rely on a JEOL 1200EX electron microscope that is now > 20 years old, and becoming increasingly difficult and expensive to maintain. Furthermore, because of its unsophisticated vacuum system it is only marginally capable of working in cryo-mode , meaning cryo-specimen optimisation and training must actually be carried out on our T-F20. We wish to purchase an FEI G2-Spirit microscope to replace the obsolete instrument, together with a CCD camera and an FEI Vitrobot freezing apparatus. The new microscope will bring dramatic benefits to EM research in Leeds. It will enable rapid collection of low-resolution and preliminary cryo data to support the substantial portfolio of structural research in Leeds. Used in conjunction with the Vitrobot freezing apparatus, it will enable optimisation of specimen preparation for frozen-hydrated specimens, enhancing the productivity of our T-F20. Finally, it will improve our ability to properly train users for a scientific career in cryo-EM, and enhance the overall productivity of the EM unit.

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Grant Details

Amount Awarded 364689
Applicant Surname Ranson
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2010-02-04T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Equipment & Resources: Inactive Scheme
Internal ID 090932/Z/09/Z
Lead Applicant Prof Neil Ranson
Other Applicant(s) Dr Stanley Burgess, Prof John Trinick, Prof Peter Knight
Partnership Value 364689
Planned Dates: End Date 2013-03-31T00:00:00+00:00
Planned Dates: Start Date 2010-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber