Maintaining the genome of germ cells, exploring and exploiting processes related to recombinational repair in C. elegans (360G-Wellcome-090944_Z_09_A)
Resolving cruciform DNA structures referred to as Holliday Junctions (HJs) is a critical step inrecombinational repair. We wish to understand how the GEN1 Holliday Junction (HJ) resolvaseworks and how it acts as a DNA damage response signalling molecule. We aim to screen forgenes that act in the gen-1 pathway to mediate DNA double strand break (DSB) repair andcheckpoint signalling. We also intend to find genes that act redundantly with gen-1 to repairDSBs. We will exploit a combination of C. elegans forward genetics and biochemistry, combinedwith complementary experimentation in the chicken DT40 tissue culture model.
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Grant Details
| Amount Awarded | 295334 |
| Applicant Surname | Gartner |
| Approval Committee | Science Interview Panel |
| Award Date | 2014-12-03T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | Senior Research Fellowship Basic |
| Internal ID | 090944/Z/09/A |
| Lead Applicant | Prof Anton Gartner |
| Partnership Value | 295334 |
| Planned Dates: End Date | 2017-04-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-08-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Julian Blow |