Diabetes and Inflammation Laboratory. (360G-Wellcome-091157_Z_10_Z)

£8,280,487

The DIL has helped identify over 40 regions of the genome that influence risk of type 1 diabetes. In each of these chromosome regions are DNA variants that alter the expression and function of genes and increase or decrease predisposition to the autoimmunity and pancreatic beta-cell destruction that causes the disease in most cases. By more detailed genetic mapping and by correlating polymorphism with alterations gene expression, splicing, protein product activity and perturbation of non-protei n coding RNAs, causal genes and their phenotypes will be identified. The effects of the major causal pathways will be modelled in vivo.

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Grant Details

Amount Awarded 8280487
Applicant Surname Todd
Approval Committee Strategic Awards Committee
Award Date 2010-04-12T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Strategic Award - Science
Internal ID 091157/Z/10/Z
Lead Applicant Prof John Todd
Other Applicant(s) Prof David Clayton, Prof Linda Wicker
Partnership Name JDRF / WT Diabetes and Inflammation Laboratory
Partnership Value 8280487
Planned Dates: End Date 2016-03-31T00:00:00+00:00
Planned Dates: Start Date 2010-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England