Diabetes and Inflammation Laboratory. (360G-Wellcome-091157_Z_10_Z)
The DIL has helped identify over 40 regions of the genome that influence risk of type 1 diabetes. In each of these chromosome regions are DNA variants that alter the expression and function of genes and increase or decrease predisposition to the autoimmunity and pancreatic beta-cell destruction that causes the disease in most cases. By more detailed genetic mapping and by correlating polymorphism with alterations gene expression, splicing, protein product activity and perturbation of non-protei n coding RNAs, causal genes and their phenotypes will be identified. The effects of the major causal pathways will be modelled in vivo.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 8280487 |
Applicant Surname | Todd |
Approval Committee | Strategic Awards Committee |
Award Date | 2010-04-12T00:00:00+00:00 |
Financial Year | 2009/10 |
Grant Programme: Title | Strategic Award - Science |
Internal ID | 091157/Z/10/Z |
Lead Applicant | Prof John Todd |
Other Applicant(s) | Prof David Clayton, Prof Linda Wicker |
Partnership Name | JDRF / WT Diabetes and Inflammation Laboratory |
Partnership Value | 8280487 |
Planned Dates: End Date | 2016-03-31T00:00:00+00:00 |
Planned Dates: Start Date | 2010-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |