Enhancement of Strategic Award (091911) entitled: Advanced Microscopy for Chromosome and RNA dynamics (360G-Wellcome-091911_Z_10_A)

We are requesting a strategic award to establish a new Wellcome Trust Centre for Chromosome and RNA dynamics that will bring together 15 leading investigators from three different Departments within the South Parks Road science campus at the University of Oxford. Our central premise is that by applying and developing advanced in vivo imaging approaches together with novel and innovative methods to track, manipulate and modify defined factors, we can achieve a new level of understanding of the me chanisms that govern the function of complex molecular machines in chromosome and RNA biology, including in the context of developing multicellular organisms. The Centre will provide the essential infrastructure for advanced imaging instrumentation, proteomics, genomics and data storage/curation as well as staff to manage facilities and analyse high volumes of data that are required to achieve our goals. It will also facilitate programs and activities through which we can build a highly interac tive and collaborative interdisciplinary environment. The Centre will significantly enhance the world leading research programmes of participating groups, and through training, mentoring and dissemination activities strengthen this key strategic area within the UK research community.