Signalling in T-cell immunity. (360G-Wellcome-092627_Z_10_Z)
The overall goal of this application is to gain a better understanding of the signalling mechanisms that regulate T-cell immunity. This understanding is needed ultimately to understand the molecular basis of T-cell function and to develop new strategies for the treatment of immune deficiencies, graft vs. host responses and autoimmune disorders. This project is divided into four aims: Aim #1: ADAP-SKAP1 regulation of inside-out pathway and immune function; Aim #2: Define the basis of ADAP-M12 b lockade of HIV-1 transcription; Aim #3: SLP-76-RanGAP and the nuclear pore complex and Aim #4: The reverse-stop signal model and chemokine reversal of CTLA-4 anergy.
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Grant Details
| Amount Awarded | 2101730 |
| Applicant Surname | Rudd |
| Approval Committee | Principal Research Fellowship Interview Committee |
| Award Date | 2010-06-10T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | Programme Grant |
| Internal ID | 092627/Z/10/Z |
| Lead Applicant | Prof Christopher Rudd |
| Partnership Value | 2101730 |
| Planned Dates: End Date | 2015-05-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-12-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Andrew Wyllie |